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    热门词:生物显微镜 水质分析仪 微波消解 荧光定量PCR 电化学工作站 生物安全柜

    现在位置时时彩网络平台>技术资料首页>行业动态>技术动态>Invetech公司和Organovo医学公司一起合作,研制出了首台商业化的3D生物打印机

    江苏7位数最新开奖18148: Invetech公司和Organovo医学公司一起合作,研制出了首台商业化的3D生物打印机

    互联网2010年6月8日 8:55 点击:4122

    时时彩网络平台 www.qlgr.net

    澳大利亚Invetech       美国Organovo

    器官移植拯救了很多人的生命,但这项技术同时也存在着器官来源不足、排异反应难以避免等弊端。那么,能否像打印纸张一样打印器官呢?这看似不可能的事情在科学家手中却已经初步变成了现实。最近,澳大利亚Invetech公司和美国Organovo公司携手研制出了全球首台商业化3D生物打印机。该打印机就像普通打印机一样,只不过普通打印机的原材料是墨水和纸,而新生物打印机的原料是人体细胞。研究人员采用事先提取好的活体,进行组合排列,打印出所需要的细胞,误差可以控制在20微米以内,得到的器官可以显著降低排异反应。这台3D打印机一次制造出器官的一层细胞,对于更为复杂的器官,打印机就在一个提前预备好的支架上排列细胞。

      目前,这种打印机还处于实验阶段,但研发人员希望其最终能够让人类随时更换细胞。

    全球首台3D生物打印机出炉  
    生物打印机“大小通吃”

      据了解,这台新款3D生物打印机由总部位于美国圣迭戈、主要从事可再生医药研发的Organovo公司以及总部位于澳大利亚墨尔本的工程和自动化公司Invetech携手研发而成,其“身价”为20万美元左右,能够打印人体的组织和器官,包括动脉和静脉血管以及其他身体器官,最终让人类实现能够随时换器官的远景目标。

      Organovo公司总裁基思·墨菲表示,该打印机可以打印出小到牙齿大到血管网在内的身体器官,其潜在用途非常广泛,但目前他们只打算用这款打印机复制一些简单的器官,比如皮肤、肌肉和较短的血管等,而且主要以研究为目的。不过,墨菲表示,公司希望在5年内完成临床试验后,用该打印机打印搭桥手术中作为“桥梁”的血管,随后打印更大、更复杂的人体器官。另外,由于该机器能够打印分岔的管状器官,因此,它也能够制造维持肾脏、肝脏、心脏等较大的活动血管网。

      这种机器也可以放进一个标准实验室的生物安全柜,在其中进行无菌操作。Invetech公司也研发出了一种以激光为基础的刻度系统,确保两个打印头都能够精确地存储材料,还可以用电脑制图系统来设计人体器官的剖面图。

      按需打印

      或成现实

      有些研究人员认为,有朝一日,这样的机器或许能够把组织和器官直接复印进入人体。的确如此,阿塔拉博士正在研制一种机器,能够扫描需要皮肤移植的身体器官,然后直接在其上复制皮肤。

      至于较大的身体器官,Organovo公司的创始人、美国密苏里大学的加博尔·福尔加奇博士认为,它们可以有不同的形状。例如,人造肾脏不需要和真肾长得一模一样,也不需要具有真肾的所有特征,它只需要能够清除血管中的垃圾就可以了。那些苦苦等候器官移植的人也不太介意移植器官的样子,只要这些器官能够工作,并且能够改善病人的身体状况就行。

      既然3D生物打印机可以按需打印人体器官,研究人员、外科医生和病人也可能不再需要对捐赠器官翘首以盼。我们可以大胆畅想,或许某一天,我们只需要轻轻按下按钮,就能让3D生物打印机制造出我们所需要的器官。
    Invetech delivers Organovo’s first commercial 3D Bio-Printer

    for manufacturing human tissue and organs
    (San Diego, Calif., and Melbourne, Australia – Dec. 1, 2009) – Invetech, an innovator in new product
    development and custom automation for the biomedical, industrial and consumer markets, today
    announced that it has delivered the world's first production model 3D bio-printer to Organovo, developers
    of the proprietary NovoGen bioprinting technology. Organovo will supply the units to research institutions
    investigating human tissue repair and organ replacement.
    Dr. Fred Davis, president of Invetech, which has offices in San Diego and Melbourne, said, “Building
    human organs cell-by-cell was considered science fiction not that long ago. Through this clever
    combination of technology and science we have helped Organovo develop an instrument that will improve
    people’s lives, making the regenerative medicine that Organovo provides accessible to people around the
    world.”
    Keith Murphy, CEO of Organovo, based in San Diego, said the units represent a breakthrough because they provide for the
    first time a flexible technology platform for organizations working on many different types of tissue construction and organ replacement.
    ”Scientists and engineers can use the 3D bio printers to enable placing cells of almost any type into a desired pattern in 3D,” said
    Murphy. “Researchers can place liver cells on a preformed scaffold, support kidney cells with a co-printed scaffold, or form adjacent
    layers of epithelial and stromal soft tissue that grow into a mature tooth. Ultimately the idea would be for surgeons to have tissue on
    demand for various uses, and the best way to do that is get a number of bio-printers into the hands of researchers and give them the
    ability to make three dimensional tissues on demand.”
    The 3D bio-printers include an intuitive software interface that allows engineers to build a model of the tissue construct before the printer commences the physical constructions of the organs cell-by-cell using automated, laser-calibrated print heads.
    To help them develop the 3D bio-printers, Organovo selected Invetech in May 2009 as their technology
    development partner. “We selected Invetech because of their capabilities for sophisticated engineering
    and automation, cultural fit as a long term partner and their consideration towards protecting Organovo’s
    bioprinting IP and maximizing our commercial return on the program. They have good processes for
    product development and project management, and it was apparent that project execution would be
    handled very well. Invetech really offered the best overall package.” said Mr. Murphy.
    Scott Dorman, engineer at Organovo, prints human
    tissues from a patient’s cells for use in creating new
    blood vessels. (Photo by Jack Smith)
     
    Invetech was asked to design and develop a highly integrated, extremely reliable and simple to use 3D
    bio-printer system which could then be transferred to manufacture and commercial sale. Because of its
    history with precision design, robotics and manufacturing products, Invetech was able to combine prior art
    with new ideas to come up with a development plan that met Organovo’s budget and design goals. The
    process advanced smoothly and on schedule with Invetech teams in Melbourne and its San Diego office,
    not far from the Organovo office.
    The printer, developed by Invetech, fits inside a standard biosafety cabinet for sterile use. It includes two
    print heads, one for placing human cells, and the other for placing a hydrogel, scaffold, or support matrix.
    One of the most complex challenges in the development of the printer was being able to repeatedly
    position the capillary tip, attached to the print head, to within microns. This was essential to ensure that
    the cells are placed in exactly the right position. Invetech developed a computer controlled, laser-based
    calibration system to achieve the required repeatability.
    Invetech plans to ship a number of 3D bio-printers to Organovo during 2010 and 2011 as a part of the
    instrument development program. Organovo will be placing the printers globally with researchers in
    centers of excellence for medical research.
    - ENDS -
    Invetech, 495 Blackburn Road, Mt Waverley (Melbourne) Vic 3149, Australia.
    Phone +613 9211 7782, Fax +613 9211 7703. Email: [email protected] Web: www.invetech.com.au
    About Invetech:
    Invetech has been creating breakthrough products and custom automation systems for more than 30 years. With
    more than 200 staff, and experience drawn from over 5,000 projects, Invetech delivers product design and
    development, contract manufacturing and custom automation services to a range of global market sectors including
    diagnostics, life sciences, medical devices, cleantech, industrial and consumer products. Operating out of locations in
    North America, Europe and Asia Pacific, our clients range from start-ups to multi-nationals.
    About Organovo:
    Organovo is a regenerative medicine company focused on delivering breakthrough human tissue printing technology
    and creating tissue on demand for research and surgical applications. The company’s NovoGen three-dimensional
    printing technology is a platform that works across all tissue and cell types. Organovo is helping physicians and
    researchers fulfill the promise of regenerative medicine by overcoming critical problems in cardiovascular medicine,
    medical research, and transplant medicine. Organovo technology leads the way in solving complex medical
    problems with one overarching goal: to benefit the health and lives of our patients. //www.organovo.com
    CONTACTS:
    Invetech, Melbourne, Australia (Office: +61 3 9211 7782)
    Roger Langsdon
    +61 417 376 433
    [email protected]
    Gable PR, San Diego (Office: 619-284-1714)
    Tom Gable
    Cell: 619-251-3881
    [email protected]


    December 1, 2009

    Organovo Develops First Commercial 3D Bio-Printer for Manufacturing Human Tissue and Organs


    SAN DIEGO, Calif. & MELBOURNE, Australia - (Business Wire) Invetech, an innovator in new product development and custom automation for the biomedical, industrial and consumer markets, today announced that it has delivered the world's first production model 3D bio-printer to Organovo, developers of the proprietary NovoGen bioprinting technology. Organovo will supply the units to research institutions investigating human tissue repair and organ replacement. Dr. Fred Davis, president of Invetech, which has offices in San Diego and Melbourne, said, "Building human organs cell-by-cell was considered science fiction not that long ago. Through this clever combination of technology and science we have helped Organovo develop an instrument that will improve people's lives, making the regenerative medicine that Organovo provides accessible to people around the world."

    Keith Murphy, CEO of Organovo, based in San Diego, said the units represent a breakthrough because they provide for the first time a flexible technology platform for organizations working on many different types of tissue construction and organ replacement.

    "Scientists and engineers can use the 3D bio printers to enable placing cells of almost any type into a desired pattern in 3D," said Murphy. "Researchers can place liver cells on a preformed scaffold, support kidney cells with a co-printed scaffold, or form adjacent layers of epithelial and stromal soft tissue that grow into a mature tooth. Ultimately the idea would be for surgeons to have tissue on demand for various uses, and the best way to do that is get a number of bio-printers into the hands of researchers and give them the ability to make three dimensional tissues on demand."

    The 3D bio-printers include an intuitive software interface that allows engineers to build a model of the tissue construct before the printer commences the physical constructions of the organs cell-by-cell using automated, laser-calibrated print heads.

    To help them develop the 3D bio-printers, Organovo selected Invetech in May 2009 as their technology development partner. "We selected Invetech because of their capabilities for sophisticated engineering and automation, cultural fit as a long term partner and their consideration towards protecting Organovo's bioprinting IP and maximizing our commercial return on the program. They have good processes for product development and project management, and it was apparent that project execution would be handled very well. Invetech really offered the best overall package." said Mr. Murphy.

    Invetech was asked to design and develop a highly integrated, extremely reliable and simple to use 3D bio-printer system which could then be transferred to manufacture and commercial sale. Because of its history with precision design, robotics and manufacturing products, Invetech was able to combine prior art with new ideas to come up with a development plan that met Organovo's budget and design goals. The process advanced smoothly and on schedule with Invetech teams in Melbourne and its San Diego office, not far from the Organovo office.

    The printer, developed by Invetech, fits inside a standard biosafety cabinet for sterile use. It includes two print heads, one for placing human cells, and the other for placing a hydrogel, scaffold, or support matrix. One of the most complex challenges in the development of the printer was being able to repeatedly position the capillary tip, attached to the print head, to within microns. This was essential to ensure that the cells are placed in exactly the right position. Invetech developed a computer controlled, laser-based calibration system to achieve the required repeatability.

    Invetech plan to ship a number of 3D bio-printers to Organovo during 2010 and 2011 as a part of the instrument development program. Organovo will be placing the printers globally with researchers in centers of excellence for medical research.

    About Invetech:

    Invetech has been creating breakthrough products and custom automation systems for more than 30 years. With more than 200 staff, and experience drawn from over 5,000 projects, Invetech delivers product design and development, contract manufacturing and custom automation services to a range of global market sectors including diagnostics, life sciences, medical devices, cleantech, industrial and consumer products. Operating out of locations in North America, Europe and Asia Pacific, our clients range from start-ups to multi-nationals.

    About Organovo:

    Organovo is a regenerative medicine company focused on delivering breakthrough human tissue printing technology and creating tissue on demand for research and surgical applications. The company's NovoGen three-dimensional printing technology is a platform that works across all tissue and cell types. Organovo is helping physicians and researchers fulfill the promise of regenerative medicine by overcoming critical problems in cardiovascular medicine, medical research, and transplant medicine. Organovo technology leads the way in solving complex medical problems with one overarching goal: to benefit the health and lives of our patients.

    (来源: 互联网 )


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