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    现在位置时时彩网络平台>技术资料首页>行业动态>技术动态>推广iPS细胞应用可减少动物实验

    江苏快三遣漏: 推广iPS细胞应用可减少动物实验

    互联网2010年6月5日 10:07 点击:1678

    时时彩网络平台 www.qlgr.net Saturday,May 08,2010

    美国科学家宣称,使用通过诱导多能干细胞(iPS细胞)得到的人体组织进行药物测试,可以减少动物实验,也可大大节约药物研发的成本,或许将大大改变药物研发的面貌。

     

     

      美国威斯康辛大学的杰米·汤普生表示,在药物研发过程中,基于iPS细胞的“试管测试”可以用于检验候选药物的安全性和有效性,测试结果证明的某些不起作用的药物就不需要进一步动物实验加以验证了,从而使成本大为节省。

      汤普生参与创办的细胞动力公司(Cellular Dynamics)正在使用iPS细胞培植心脏细胞,并将培植好的心脏细胞提供给研发心脏病药物的制药公司使用。该公司计划明年从具有特定民族背景或者特定基因特征的人身上提取iPS细胞,然后使之发育成心脏细胞以用于药物测试,任何可能给特定的基因或者特定民族的人带来副作用的药物或许都将被撤销。

      汤普生表示,如果他们正在进行的研究取得成功,将会大大减少动物实验,最终可能不需要动物实验。另外,通过iPS细胞得到的人体组织甚至能够提供比动物更好的实验模型,这也可以让科学家更好地了解人体本身,或许将大大改变人类医药研究的面貌。


    Cellular Dynamics is the world’s largest producer of fully functional human cells derived from induced pluripotent stem (iPS) cells. In a field only a few decades old, CDI scientists tout more than 275 years combined of stem cell experience. Building on this expertise, our iCell™ products provide industrialized quantities of terminally differentiated human cells enabling basic research, efficient drug discovery programs, and reliably predictive toxicity and efficacy screening through in vitro clinical trials.

     

    New stem cells will reduce the need for animal testing

    Powerful stem cells made by reprogramming adult tissue could reduce the need for animal testing of new drugs, according to a scientific pioneer of the technology.

    Jamie Thomson, of the University of Wisconsin, told The Times that “in-vitro trials” based on so-called induced pluripotent stem (IPS) cells would refine pharmaceutical development so that fewer animal experiments would be required.

    The cells were already being used as a source of human tissue for testing candidate drugs for safety and effectiveness, he said. As a result, fewer unworkable drugs would advance to animal studies, and some animal tests may become unnecessary.

    “If what we are doing is successful it will dramatically reduce animal testing, and maybe towards the end of our lifespan actually eliminate it for some things,” Professor Thomson said. “I think we will have much better models for these things.”

    IPS cells, which were created in 2007 by teams led by Professor Thomson and Professor Shinya Yamanaka, of Kyoto University in Japan, are made by manipulating adult skin tissue to give it versatile properties of embryonic stem (ES) cells.

    These master cells can be grown into any type of tissue, offering a limitless source of specialised cells for use in research. There is hope that they may eventually be used to produce cell therapies for Parkinson’s disease, diabetes and paralysis. As IPS cells are made without destroying embryos, their use is ethically acceptable.

    Cellular Dynamics, a company founded by Professor Thomson, is already using IPS cells to grow heart cells for pharmaceutical companies to use in the development of cardiac drugs.

    Next year Cellular Dynamics will produce heart cells using IPS cells taken from people with particular ethnic backgrounds or genetic traits. Any candidate drugs that have damaging side-effects on cells with a particular genetic profile or on cells from people from certain ethnic groups could then be withdrawn, averting the failure of an expensive full-patient trial.

    As much of this toxicity testing is currently performed in animals, there is great potential for reducing the number of animal experiments.

    Human tissue grown from IPS cells may even provide a better laboratory model than animals, Professor Thomson said. “I trained as a veterinary pathologist, and the correlation [between results in animal and human trials] is not that great at the end of the day,” he said.

    Professor Thomson said that the chief value of IPS cells would be as laboratory models for studying disease and testing drugs, rather than cell replacement. While it may prove possible to grow patient-specific spare-part tissue, which would not risk immune rejection, the costs are high.

    “This gives us access to the basic building blocks of the human body,” he said. “We’ll learn a tremendous amount about the human body, and that will profoundly change human medicine.”

    The master key

    — Stem cells are master cells from which all types of human tissue are ultimately derived

    — Induced pluripotent stem (IPS) cells, pictured, are made by genetically modifying skin cells. This turns them into an embryo-like state, allowing them to develop into any type of tissue.

    — IPS cells are acceptable to some opponents of embryo research, and as they are grown from skin they can carry genetic characteristics.

    — Adult stem cells are less powerful than IPS or embryonic stem cells, as they have already started to “specialise”. They can be used to make only a narrower range of tissue.

    (来源: 互联网 )


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