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    热门词:生物显微镜 水质分析仪 微波消解 荧光定量PCR 电化学工作站 生物安全柜

    现在位置时时彩网络平台>技术资料首页>行业动态>技术动态>美国马萨诸塞州总医院研究员成功利用大鼠细胞,在实验室培育出人造肝??蒲Ъ蚁M庀钛芯?年内可在医院应用,协助人类培植肝脏。

    江苏体彩网: 美国马萨诸塞州总医院研究员成功利用大鼠细胞,在实验室培育出人造肝??蒲Ъ蚁M庀钛芯?年内可在医院应用,协助人类培植肝脏。

    互联网2010年6月16日 12:59 点击:2096

    据香港《文汇报》6月15日报道,美国马萨诸塞州总医院研究员成功利用大鼠细胞,在实验室培育出人造肝??蒲Ъ蚁M庀钛芯?年内可在医院应用,协助人类培植肝脏。
     
    马萨诸塞州总医院研究员先去掉大鼠肝脏上的细胞,剩下一个“支架”,然后将2亿个健康的肝细胞分4次、每次10分钟注射到支架上进行培植,成功培植出人造大鼠活肝,在实验室存活10天之久,并能够分解毒素;另外,研究员还将人造肝移植到大鼠身上,发现它能正常运作数小时。有关报告刊登在《自然—医学》杂志上。
     
    实验中只使用了一种肝细胞,培植出的人造肝也只能发挥正常肝功能的一小部分作用。
     
    研究员称,今后将实验加入肝脏所需的其它细胞,并研究令培植肝长期正常运作,以便最终能移植到人体内。
     


    Researchers develop functional, transplantable rat liver grafts

    June 13, 2010

    时时彩网络平台 www.qlgr.net A team led by researchers from the Center for Engineering in Medicine at Massachusetts General Hospital (MGH) has developed a technique that someday may allow growth of transplantable replacement livers. In their report that will be published in Nature Medicine and is receiving early online release, the investigators describe using the structural tissue of rat livers as scaffolding for the growth of tissue regenerated from liver cells introduced through a novel reseeding process.

     

     

    "Having the detailed microvasculature of the liver within a biocompatible, natural scaffold is a major advantage to growing liver tissue in a synthetic environment," says Basak Uygun, PhD, research associate at the MGH Center for Engineering in Medicine (MGH-CEM) and the paper's lead author. "Our technique of 'decellularizing' organs leaves the vascular system intact, which facilitates repopulation of the structural matrix and the subsequent survival and function of the introduced liver cells."

    is the only effective treatment for but is greatly limited by the shortage of donor organs. Each year 4,000 individuals who might have survived with a liver transplant die in the U.S. The shortage of donor livers and other organs is a major force behind the emerging field of tissue engineering and regenerative medicine. Efforts to build tissues from the ground up have not yet approached the goal of transplantable replacement organs, and replacing the liver - in which each cell is a metabolic factory requiring constant, direct contact with the - has been particularly challenging.

    The current report describes a refinement of an approach to re-engineering replacement rat hearts that was reported in 2008 by University of Minnesota researchers. Since liver tissue is much more delicate than the muscular structure of the heart, the MGH-CEM team developed a gentler way of flushing living cells out of the liver's structural matrix, which is primarily made of connective tissue like collagen. After the cells were removed, the lobular structure of the liver and its extracellular matrix remained. Containing specific biochemical signals and cues that would direct to travel to the correct location and resume function - something quite difficult to replicate using synthetic methods - the matrix also maintained the organ's intricate network of blood vessels.  

    Another novel technique was used to reintroduce hepatocytes, the cells that carry out most of the liver's primary functions, into the decellularized matrix. The MGH-CEM approach actually caused cells to penetrate the vascular network and become embedded in the matrix, leaving major vessels clear to carry the essential blood supply. The repopulated matrix displayed normal liver function for up to 10 days in culture, and recellularized grafts were successfully connected to the circulation of live rats with minimal cellular damage and normal hepatocyte function.

    "As far as we know, a transplantable liver graft has never been constructed in a laboratory setting before," explains Korkut Uygun, PhD, of the MGH-CEM, the paper's senior author. "Even though this is very exciting and promising, it is a proof-of-concept study only. Much more work will be required to make long-term functional liver grafts that can actually be transplanted into humans. We haven't been able to go beyond several hours in the rats, but it's a great start."

    Martin Yarmush, MD, PhD, director of the MGH-CEM and a co-author of the study, explains that the quarter of a million donor livers discarded each year because they are not suitable for transplantation would be an obvious source of supply for the creation of whole-organ scaffolds. "There is great potential for constructing full-fledged liver lobes containing animal or human cells, but several thorny issues must first be tackled, including formation of a layer of endothelial cells to line graft blood vessels," he says. "Given enough careful work, this approach could ultimately revolutionize tissue engineering and provide real working grafts for the liver and other complex tissues." Yarmush and Korkut Uygun both have faculty appointments at Harvard Medical School.
     

    Provided by Massachusetts General Hospital (news : web)

    (来源: 互联网 )


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