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    现在位置时时彩网络平台>技术资料首页>行业动态>公司动态>Quark Pharmaceuticals宣布将展示两款siRNA备选药物出席Glaucoma & Retinopathies 2010

    江苏11选五开奖结果: Quark Pharmaceuticals宣布将展示两款siRNA备选药物出席Glaucoma & Retinopathies 2010

    Quark Pharmaceuticals2010年6月25日 10:19 点击:2658

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    Quark Pharmaceuticals宣布将展示两款siRNA备选药物出席Glaucoma & Retinopathies 2010

     



    FREMONT, Calif., Jun 24, 2010 -  Quark Pharmaceuticals, Inc., a world leader in the discovery and development of RNAi-based therapeutics, today announced that two of its siRNA drug candidates were featured in the following two presentations at the Glaucoma & Retinopathies 2010 conference, which was held June 21-22, 2010 in London, UK:

    • “QPI-1007, an ocular neuroprotective siRNA for ameliorating RGC (retinal ganglion cell) loss,” presented by Elena Feinstein, Chief Scientific Officer of Quark Pharmaceuticals.
    • “Interference RNA for the treatment of AMD and DME,” presented by Kay Rittenhouse, Head Translational Medicine Ophthalmology, Specialty Care Business Unit, Pfizer.
    QPI-1007 is a potent neuroprotective siRNA and Quark’s first siRNA drug candidate having proprietary structure and chemical modifications. The presentation highlighted preclinical data on the pharmacological features of QPI-1007 and its ocular neuroprotective effects in three different animal models – optic nerve crush, optic nerve axotomy and ocular hypertension model of glaucoma. The presentation also discussed clinical prospects for QPI-1007 as a treatment for non-arteritic ischemic optic neuropathy (NAION), the subject of a Phase I/II clinical trial currently underway.

    Dr. Feinstein said, “We are pleased to present additional data supporting the neuroprotective effects of QPI-1007 and its potential in NAION. Preclinical data in rat models of glaucoma are also particularly encouraging because both rats and humans undergo retinal ganglion cells damage as a result of glaucoma. We believe that these animal models are most appropriate for supporting clinical studies in humans, and look forward to further evaluating our first siRNA drug with internally developed structure.”

    The subject of the presentation by Dr. Rittenhouse was the siRNA compound PF-655 developed by Quark that targets Quark’s proprietary gene, RTP801. PF-655 is currently in two Phase II clinical trials, in wet age-related macular degeneration (AMD) and diabetic macular edema (DME). Quark licensed this siRNA therapeutic candidate to Pfizer in 2006; and Pfizer is currently conducting both trials in collaboration with Quark. The presentation reviewed a collection of studies on the efficacy of PF-655 in both preclinical models of diabetic retinopathy and wet-AMD. PF-655 inhibited expression of RTP801 in a dose-related manner, starting as early as from day one after its single intravitreal administration, for up to 14 days. The RNAi effect may have a longer duration in retinal pigmented epithelium/choroid tissues. In addition, PF-655 decreased fluorescein leakage, a wet-AMD endpoint that is translatable in humans.

    Dr. Rittenhouse said, “These preclinical results are consistent with the rationale for our ongoing Phase II clinical studies of PF-655 in both DME and wet-AMD.”

    Glaucoma and Retinopathies 2010 focused on the latest advances in ocular neuroprotection, drug delivery and anti-vascular therapies. With the number of older people and diabetics rising worldwide, the glaucoma and retinal disease markets will double by 2020. These will remain the largest and fastest-growing areas of the ophthalmic pharmaceuticals market, with combined worldwide revenues of $20bn by 2025, according to Visiongain.


    About Quark Pharmaceuticals, Inc.

    Quark Pharmaceuticals, Inc., the world leader in novel RNAi discovery and development, has the largest clinical-stage siRNA pipeline in the industry. The Company’s fully integrated drug development platform spans therapeutic target identification to drug development. Quark’s approach to siRNA delivery allows targeting of several tissues and organs including the eye, kidney, inner ear, lung, spinal cord and brain.

    Quark’s pipeline is led by PF-04523655, currently in two Phase II clinical trials for the treatment of wet age-related macular degeneration (AMD) and diabetic macular edema (DME). The siRNA therapeutic candidate was licensed to Pfizer in 2006 and both trials are being conducted by Pfizer in collaboration with Quark. PF-04523655 targets Quark’s proprietary gene, RTP801, discovered using its proprietary BiFAR™ target discovery platform that identifies clinically relevant critical genes and proteins that reverse the disease phenotype when inhibited. The Company owns several families of patents covering the RTP801 gene, its RNA and protein product sequences, specific antibodies, and gene inhibition across different pathologies.

    Quark’s is also evaluating QPI-1002, the first systemically administered siRNA drug in human clinical trials. Enrollment was successfully completed in Phase I studies of QPI-1002 for the prevention of acute kidney injury (AKI) following major cardiovascular surgery and the prophylaxis of delayed graft function after kidney transplantation. Phase II clinical studies are planned to commence shortly. For the structure of these products, Quark has obtained licenses from Silence Therapeutics and from Alnylam Pharmaceuticals.

    Quark is currently conducting clinical trials of QPI-1007, its proprietary synthetic siRNA drug candidate for ocular neuroprotection. QPI-1007 utilizes a proprietary structure developed in collaboration with BioSpring GmbH that provides Quark with freedom to operate in the siRNA intellectual property arena and chemical modifications that are designed to preserve RNAi activity while ameliorating potential off-target and immunostimulatory effects of siRNAs.

    Quark is also committed to leveraging a broad research pipeline of siRNA drug candidates and novel siRNA structures to develop additional RNAi drug candidates.

    Quark is headquartered in Fremont, California and operates research and development facilities in Boulder, Colorado and Ness-Ziona, Israel. Additional information is available at  www.quarkpharma.com

                                          # # #
    Quark Pharmaceuticals, Inc.       The Ruth Group (investors / media)
    Juliana Friedmann
    +972 89 30 5111
    [email protected]
      Sara Pellegrino / Jason Rando
    (646) 536-7002 / 7025
    [email protected]
    [email protected]
    (来源: Quark Pharmaceuticals )


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