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    现在位置时时彩网络平台>技术资料首页>行业动态>人物>何大一M.D.(David Ho 华裔美国科学家,是艾滋病鸡尾酒疗法的发明人。

    时时彩规律口诀: 何大一M.D.(David Ho 华裔美国科学家,是艾滋病鸡尾酒疗法的发明人。

    互联网2010年6月5日 10:43 点击:8167

    时时彩网络平台 www.qlgr.net 何大一M.D.(David Ho,1952年11月3日-),华裔美国科学家,是艾滋病鸡尾酒疗法的发明人。 //www.adarc.org/
     何大一M.D.(David Ho
    人物介绍
      何大一,1952年11月3日出生于中国台湾台中市,祖籍江西新余,12岁时移民美国加利福尼亚州洛杉矶市。1981年,在洛杉矶Cedars-Sinai医学中心当见习医生时接触到了最早发现的一批艾滋病病例,1994年开始研究“鸡尾酒”疗法治疗艾滋病。1999年,何大一及其同事又发现人体免疫系统T细胞中的CD8可以有效对抗艾滋病毒。2000年,又研制出C型艾滋病疫苗,目前已进入临床实验阶段。目前是美国纽约洛克菲勒大学艾伦·戴蒙德艾滋病研究中心主任、教授,美国科学院院士,中国工程院外籍院士。   国际防治艾滋病权威何大一,天生一张娃娃脸,使年过半百的他看上去比实际年龄年轻许多,尤其他穿西装不打领带,肩挎着背包,更像一个腼腆的大学生。近5年来,何大一在中国艾滋病高发地区往来奔波,对中国艾滋病防治事业倾注了大量心血。
    人物生平
      何大一(1952年11月3日生),美籍华裔科学家,是艾滋病鸡尾酒疗法的发明人。   何大一祖籍江西,出生于台湾台中市,现居美国纽约。在何大一9岁的时候,其父亲何步基(Paul Ho)赴美国谋生。12岁时何大一移民美国加利福尼亚州洛杉矶市,与其父亲团聚。何大一的母亲Sonia Ho,有两个弟弟:何弘一(Phillip Ho)和何纯一(Sidney Ho)。   何大一博士1970年考入美国麻省理工学院,1974年以第一名的成何大一绩(summa cum laude)获得学士学位。同年入哈佛大学就读,在1978年获得哈佛大学医学院医学博士学位。1978年到1982年期间在加州大学洛杉矶分校医学院,1982-1985年期间在马萨诸塞州综合医院分别进行进行内科和传染病学的临床实践。1981年,何大一在洛杉矶Cedars-Sinai医学中心当见习医生时接触到了最早发现的一批艾滋病病例。   何大一是世界上最早认识到艾滋病是由病毒引起的科学家之一,也是首先阐明艾滋病病毒复制多样性的科学家之一。正是基于这种理解,使得何大一和他的同事们致力于研究联合抗病毒疗法,即鸡尾酒疗法。这种疗法将蛋白酶抑制剂药物和核苷类逆转录酶抑制剂及非核苷类逆转录酶抑制剂药物组合使用,能更有效地治疗艾滋病。1996年在发达国家使用以来,有效降低了艾滋病人死亡率。   1999年,何大一及其同事又发现人体免疫系统T细胞中的CD8可以有效对抗艾滋病毒。2000年,又研制出C型艾滋病疫苗,目前已进入临床实验阶段。何大一  何大一目前是美国纽约洛克菲勒大学艾伦·戴蒙德艾滋病研究中心主任、教授。同时还是美国科学院院士,中国工程院外籍院士,台湾“中央研究院”院士。因为发明鸡尾酒疗法,1996年被美国《时代》周刊评选为当年的年度风云人物。   1997年新余市人民政府授予何大一博士荣誉市民,并聘请为科学顾问,渝水区人民政府在区府大院奖励了何大一博士一套三室二厅住房。   2000年何大一博士出席了由全国青联、香港特别行政区政府民政事务局、北京市政府、中央电视台等单位主办的以海内外华人精英为主的“迈向新世纪”研讨会,并在大会上作代表发言。   2004年6月2日是获得中国工程院士殊荣的五名外籍人士之一。突出贡献是对艾滋病的研究治疗。   2007年11月,清华大学艾滋病综合研究中心成立,何大一出任主任。   2008年11月6日香港大学授予名誉科学博士。
    家庭
      住在纽约的何大一与妻子郭素玉育有三个孩子,老大是女儿,获得企管硕士后现在洛杉矶雅虎服务,老二是儿子,麻省理工学院毕业后现从事商业分析师工作。最小的是女儿,现就读于麻省理工学院,主修生物学,稍与父亲的专长有关。何大一强调说:“我不强迫小孩跟我一样,他们能够追寻自己的热情,才是最重要的。”
     鸡尾酒疗法
      何大一在研究中发现,艾滋病毒在传播和繁殖的过程中,经常发生一些结构和功能的变化,这时即使使用原先可能很有效的药,此时也不管用了,导致病毒可以继续在体内大量繁殖。这使何大一想到,单一的药物治疗可很快产生抗药性,应该针对艾滋病病毒感染人体的不同环节,用三种或三种以上的药物通过联合用药来提高治疗效果,最大限度地抑制病毒的复制。何大一将这种治疗方法形象地命名为“鸡尾酒”疗法。   “鸡尾酒”疗法公布后,立即轰动了整个医学界,现在普遍使用鸡尾酒疗法的国家,艾滋病人的死亡率已经下降到了20%。   “鸡尾酒”疗法虽然不能完全治愈艾滋病,但它是目前阻断艾滋病进攻的最有效的办法。1996年,何大一因此被美国著名的《时代》周刊评选为年度风云人物。2001年1月,美国时任总统克林顿向他颁发了“总统国民勋章”。


    David Da-i Ho (traditional Chinese: 何大一; born November 3, 1952) is a Chinese American[1] AIDS researcher famous for pioneering the use of protease inhibitors in treating HIV-infected patients with his team.[2]

    Born in Taichung, Taiwan to Paul (an engineer) and Sonia Ho, from Jiangxi Province who fled to Taiwan from the Mainland in 1949, David Ho immigrated at the age of twelve to the United States with his mother and younger brother to unite with his father, who had already been in the US for nine years. He grew up in Los Angeles and received his bachelor of science in physics with highest honors from the California Institute of Technology (1974) and MD from the Harvard-MIT Division of Health Sciences and Technology (1978). Subsequently, he did his clinical training in internal medicine and infectious diseases at UCLA School of Medicine (1978-1982) and Massachusetts General Hospital (1982-1985), respectively. He was a resident in internal medicine at Cedars-Sinai Medical Center in Los Angeles in 1981 when he came into contact with some of the first reported cases of what was later identified as AIDS.

    Living in Chappaqua, New York, Ho is married to artist Susan Kuo, with whom he has three children: Kathryn, Jonathan, and Jaclyn. He is a member of the Committee of 100, a Chinese American leadership organization, in addition to several scientific groups.

    [edit] Research
    Ho has been at the forefront of AIDS research for 26 years. He published over 350 papers, enabling the scientific community to understand the mechanism of HIV replication.[3] He championed the combination anti-retroviral therapy[4] which allowed the control of HIV replication in patients.[5] AIDS mortality has declined six times in developed countries since 1996, and international efforts are under way to bring the treatment to patients in the developing world.

    Ho shifted his work from treating late in the illness to finding ways to fight the disease early on. Ho helped devise the HAART or highly active anti-retroviral therapy, which prescribes a cocktail of drugs to treat AIDS, on the theory that it would be more effective to combine powerful protease inhibitors with other HIV medications.

    Ho’s research team is now working on developing vaccines for AIDS. He heads a consortium of organization in China and the U.S. to address the crisis of HIV/AIDS in China.

    [edit] Honors and titles
    Ho has received numerous honors and awards for his scientific accomplishments. He is the recipient of ten honorary doctorates, including from Swarthmore, Tufts, Columbia, Tulane, University of Natal, and Tsinghua University. He has been chosen as the commencement speaker at Caltech, MIT, and Harvard School of Public Health. Other accolades include the Ernst Jung Prize in Medicine, Mayor’s Award for Excellence in Science & Technology, the Squibb Award, and the Hoechst Marion Roussel Award. On January 8, 2001, Ho was presented with the Presidential Citizens Medal by President Clinton.

    Ho is an honorary professor at Peking Union Medical College, Chinese Academy of Medical Sciences, Chinese Academy of Sciences, University of Hong Kong, Wuhan University, and Fudan University. He was a member of the Board of Overseers of Harvard University and the Board of Trustees of the California Institute of Technology. He is a board member of the Massachusetts Institute of Technology Corporation.

    Ho was Time magazine's 1996 Man of the Year. Time later recalled the selection surprised both Ho and readers, with one reader calling Ho "Dr. David Who?"[6] The magazine acknowledged in 1996 that "Ho is not, to be sure, a household name. But some people make headlines while others make history."[6] Ho was even briefly mentioned when Alexander Fleming was considered for Person of the Century in 1999, since Fleming could be portrayed as representative of other scientists including Ho,[7] but the title ultimately went to Albert Einstein.

    Ho has been elected as a member of the American Academy of Arts and Sciences, Academia Sinica, and the Institute of Medicine of the National Academy. He is currently the scientific director and chief executive officer of the Aaron Diamond AIDS Research Center and the Irene Diamond Professor at the Rockefeller University in New York.

    On 2006-12-06, California governor Arnold Schwarzenegger and First Lady Maria Shriver inducted Ho into the California Hall of Fame located at The California Museum for History, Women, and the Arts.

    [edit] Quotes
    "This is a problem for the world and therefore we're going to solve it."
    "I began with an interest in this medical curiosity, never realizing that this was going to be a big health problem for the public. But, the scientific aspect was extremely interesting in that here we were looking at something that was transmissible, capable of destroying the immune system. That was new and one way or another the science behind that would shed light on bugs and on the immune system. So, I was gung-ho from day one of the epidemic."
    [edit] Sources
    The White House - President Clinton Awards the Presidential Citizens Medals Monday, January 8, 2001
    [edit] References
    ^ "Public Affairs Television "Becoming American" Interview with David Ho, M.D.". PBS. //www.pbs.org/becomingamerican/ap_pjourneys_transcript3b.html. Retrieved 2008-02-12.
    ^ "Scientist David Ho: The Man Who Could Beat AIDS". Time. //www.time.com/time/magazine/article/0,9171,1953703-1,00.html. Retrieved 24 January 2010.
    ^ (Nature 1995; Science 1996)
    ^ (N. Engl. J. Med. 1995; Science 1996)
    ^ (Nature 1997)
    ^ a b Time, Person of the Year: 75th Anniversary Celebration, Special Collector's Edition, Time Books, 2002, p. 108.
    ^ Time Millennium, Collector's Edition, Time Inc. Specials, p. 21.
     

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